Japanese researchers found that a soy-derived compound, LPC70, protected mice on a high-salt diet from hypertension, memory loss and social withdrawal by selectively altering prostaglandin signalling in the kidneys and brain.
01Summary
- 01Mice fed a high-salt diet developed elevated blood pressure, reduced social interaction and impaired object recognition memory.
- 02Supplementing the diet with LPC70 lowered blood pressure and improved performance in social and memory tests.
- 03In the kidneys, LPC70 reduced salt-induced increases in COX-2 and the PGE2 receptor EP3, linked to hypertension.
- 04In the prefrontal cortex, LPC70 restored expression of the protective PGD2 receptor DP1 without affecting the harmful DP2 receptor.
- 05The study, led by Prof. Akihiro Mouri and Dr. Hisayoshi Kubota at Fujita Health University, was published in Neurochemistry International on July 1, 2026.
02Why it matters
This research suggests a natural dietary compound could help counteract the brain and blood-pressure damage caused by excessive salt intake, offering a potential strategy to protect cognitive and social function without requiring drastic salt reduction.
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